4.1 Article

Role of N-methyl-D-aspartate receptor antagonists in postoperative pain management

Journal

CURRENT OPINION IN ANESTHESIOLOGY
Volume 22, Issue 5, Pages 618-622

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ACO.0b013e32832e7af6

Keywords

acute pain; hyperalgesia; N-methyl-D-aspartate; N-methyl-D-aspartate receptor antagonists

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Purpose of review In recent years, hundreds of studies have examined the clinical efficacy of N-methyl-D-aspartate (NMDA) receptor antagonists such as ketamine and dextromethorphan as an adjunct to routine postoperative pain management. The purpose of this review is to a describe the detail of the study that successfully demonstrated the efficacy of NMDA receptor antagonists. Recent findings The effect of perioperative ketamine infusion, dextromethorphan, and memantine on postoperative opioid-induced analgesia and prevention of long-term persistent pain is described. Summary The co-administration of ketamine and morphine as a mixture is not recommended for postoperative pain relief. As an adjunct in multimodal analgesia, low-dose ketamine infusion and the administration of dextromethorphan may be able to improve postoperative pain status. Memantine exhibits the greatest potency among NMDA receptor antagonists. In future, research should consider the perioperative infusion of ketamine followed by long-term administration of memantine for the prevention of persistent pain.

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