Journal
JOURNAL OF NEUROPHYSIOLOGY
Volume 114, Issue 4, Pages 2080-2083Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00998.2014
Keywords
periaqueductal gray; chronic low back pain; descending pain modulation; resting-state fMRI
Categories
Funding
- Arthritis Society
- University of Toronto Centre
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In this Neuro Forum we discuss the significance of a recent study by Yu et al. (Neuroimage Clin 6: 100-108, 2014). The authors examined functional connectivity of a key node of the descending pain modulation pathway, the periaqueductal gray (PAG), in chronic back pain patients. Altered PAG connectivity to pain-related regions was found; we place results within the context of recent literature and emphasize the importance of understanding the descending component of pain in pain research.
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