4.6 Article

General Anesthetic Actions on GABA(A) Receptors

Journal

CURRENT NEUROPHARMACOLOGY
Volume 8, Issue 1, Pages 2-9

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157015910790909502

Keywords

GABA(A) Receptor; General Anesthetic; Isoflurane; Desflurane; Sevoflurane; Propofol; Etomidate; Barbiturates

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General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABA(A) receptor. In this review we will discuss what is known about anesthetic - GABA(A) receptor interactions.

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