4.6 Review

Adenosine A(2A) Receptors in Psychopharmacology: Modulators of Behavior, Mood and Cognition

Journal

CURRENT NEUROPHARMACOLOGY
Volume 7, Issue 3, Pages 195-206

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157015909789152191

Keywords

Adenosine; A(2A) receptor; caffeine; psychostimulant; amphetamine; cocaine; schizophrenia; anxiety; depression; dopamine; glutamate

Funding

  1. National Institute of Health [MH083973, DA19362]
  2. NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH083973] Funding Source: NIH RePORTER

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The adenosine A(2A) receptor (A(2A)R) is in the center of a neuromodulatory network affecting a wide range of neuropsychiatric functions by interacting with and integrating several neurotransmitter systems, especially dopaminergic and glutamatergic neurotransmission. These interactions and integrations occur at multiple levels, including (1) direct receptor-receptor cross-talk at the cell membrane, (2) intracellular second messenger systems, (3) trans-synaptic actions via striatal collaterals or interneurons in the striatum, (4) and interactions at the network level of the basal ganglia. Consequently, A(2A)Rs constitute a novel target to modulate various psychiatric conditions. In the present review we will first summarize the molecular interaction of adenosine receptors with other neurotransmitter systems and then discuss the potential applications of A(2A)R agonists and antagonists in physiological and pathophysiological conditions, such as psychostimulant action, drug addiction, anxiety, depression, schizophrenia and learning and memory.

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