Journal
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
Volume 14, Issue 6, Pages -Publisher
SPRINGER
DOI: 10.1007/s11910-014-0450-z
Keywords
Essential tremor; Biology; Pathophysiology; Cerebellum
Categories
Funding
- NINDS NIH HHS [R01 NS085136, R01 NS042859] Funding Source: Medline
Ask authors/readers for more resources
For many years, little was written about the underlying biology of ET, despite its high prevalence. Discussions of disease mechanisms were dominated by a focus on tremor physiology. The traditional model of ET, the olivary model, was proposed in the 1970s. The model suffers from several critical problems, and its relevance to ET has been questioned. Recent mechanistic research has focused on the cerebellum. Clinical and neuroimaging studies strongly implicate the importance of this brain region in ET. Recent mechanistic research has been grounded more in tissue-based changes (i.e., postmortem studies of the brain). These studies have collectively and systematically identified a sizable number of changes in the ET cerebellum, and have led to a new model of ET, referred to as the cerebellar degenerative model. Hence, there is a renewed interest in the science behind the biology of ET. How the new understanding of ET will translate into treatment changes is an open question.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available