Journal
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
Volume 15, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1007/s11910-014-0504-2
Keywords
Anticoagulants; Apixaban; Dabigatran; Intracerebral hemorrhage; Target-specific oral anticoagulants; Prothrombin complex concentrate; Rivaroxaban; Vitamin K; Warfarin
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Anticoagulant therapies are increasingly being used for the treatment and prevention of thromboembolic diseases. A growing incidence of anticoagulant-associated intracranial hemorrhage (AICH) has accompanied the rise in their use. Although the rate of intracerebral hemorrhage (ICH) in patients receiving anticoagulation therapies such as heparin and target-specific oral anticoagulants (TSOAs) is significantly lower than that of vitamin K antagonists (VKAs), the mortality rate remains high. TSOAs have only recently become available for use in clinical practice, and presently, there is a paucity of both clinical data and evidence-based guidelines to assist in the management of TSOA-associated intracerebral hemorrhage. In this article, we review current literature and provide physicians with diagnostic and therapeutic considerations for the management of AICH.
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