Journal
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
Volume 10, Issue 3, Pages 167-173Publisher
SPRINGER
DOI: 10.1007/s11910-010-0099-1
Keywords
Cortical spreading depression (CSD); Migraine; Familial hemiplegic migraine (FHM); Hormones; Aura; Trigger
Categories
Ask authors/readers for more resources
Cortical spreading depression, a slowly propagating wave of transient neuronal and glial depolarization, is widely accepted as the electrophysiologic substrate of migraine aura and a trigger for headache. Recent clinical and experimental evidence reinforces the putative role of cortical spreading depression in migraine pathophysiology. Imaging studies in migraineurs demonstrated hemodynamic changes consistent with cortical spreading depression during aura, whereas recent animal studies helped unravel pathophysiologic aspects such as the triggering mechanisms, genetic and hormonal modulation, and potential therapeutic targets. Here, we provide an overview of recent advances in our understanding of migraine pathophysiology and treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available