Journal
CURRENT MOLECULAR MEDICINE
Volume 14, Issue 4, Pages 543-554Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1566524014666140414205943
Keywords
Angiogenesis; cancer; G protein coupled receptors (GPCR); tumor; vascular biology; vascular endothelial growth factor (VEGF)
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Funding
- National Basic Research Program of China [2012CB910402]
- National Natural Science Foundation of China [30930055]
- DOD [W81XWH-10-1-0147]
- NIH [R01CA106479]
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G protein-coupled receptor 124 (GPR124; also called tumor endothelial marker 5, TEM5) is highly expressed in tumor vasculature. While recent studies have revealed a role in vasculogenesis, evidence for GPR124 function in tumor angiogenesis is lacking. Here, we demonstrate that GPR124 is required for VEGF-induced tumor angiogenesis. GPR124 silencing in human endothelial cells inhibited mouse xenograft tumor angiogenic vessel formation and tumor growth. GPR124 regulated VEGF-induced tumor angiogenic processes in vitro including cell-cell interaction, permeability, migration, invasion, and tube formation. Therefore, GPR124 plays a key role in VEGF-induced tumor angiogenesis.
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