Journal
CURRENT MOLECULAR MEDICINE
Volume 12, Issue 6, Pages 698-703Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156652412800792598
Keywords
Reactive Oxygen Species (ROS); Oxidative Stress; Lipid Oxidation; DNA Oxidation; Protein Oxidation; Oral Carcinogenesis; OSCC; Leukoplakia; Lichen Planus; Submucous Fibrosis
Categories
Funding
- National Institutes of Health [P20RR17675]
- Centers of Biomedical Research Excellence (COBRE)
- Layman Award from the University of Nebraska-Lincoln
- Marie Curie International Reintegration Grant within the 6th European Community Framework Program [MIRG-CT-2006-036585]
- Biology Department, ECU
- Hellenic Republic
- Ministry of National Education and Religious Affairs
- General Directorate of European & International Affairs
- Directorate of International Relations in Education
- Department of Scholarships
- School of Community Health Sciences
- Junior Faculty Research Award from the University of Nevada-Reno
- Marie Curie International Reintegration Grant within the 7th European Community Framework Program [PIRG05-GA-2009-249315]
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Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, oxidative stress implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidative-modified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis.
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