Journal
CURRENT MICROBIOLOGY
Volume 62, Issue 4, Pages 1331-1336Publisher
SPRINGER
DOI: 10.1007/s00284-010-9866-0
Keywords
-
Categories
Funding
- Polish Ministry of Sciences and Higher Education through the Faculty of Biology, University of Warsaw [BW 179132, BW 183115]
Ask authors/readers for more resources
The pentacyclic triterpenoids, oleanolic, and ursolic acids, affect peptidoglycan metabolism, altering bacterial morphology, and inhibit the growth and survival of several bacterial species, including pathogenic ones. We investigated the effect of subinhibitory concentrations of these compounds on the expression of three operons from the E. coli cysteine regulon, cysPTWA, cysJIH, and cysB, by using transcriptional fusions with the lacZ reporter gene. An inhibitory effect on beta-galactosidase expression directed by all three chromosomal fusions was observed with both compounds. In addition, oleanolic acid, but not ursolic acid, caused a weak increase in DnaK synthesis, suggesting moderate ability of inducing heat-shock response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available