Journal
CURRENT MICROBIOLOGY
Volume 62, Issue 3, Pages 758-763Publisher
SPRINGER
DOI: 10.1007/s00284-010-9774-3
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Funding
- Rajiv Gandhi Centre for Biotechnology, Trivandrum, India
- Council of Scientific and Industrial Research, Govt. of India
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Vibrio cholerae is causative agent of life threatening diarrheal disease, cholera. The toxin co-regulated pilus (TCP) is a critical colonization factor of V. cholerae and it also serves as receptor for CTXDcurrency sign. In this study, we describe nucleotide sequence of four novel alleles of tcpA gene from toxigenic and non-toxigenic V. cholerae isolated from environmental sources. The phylogenetic analysis of tcpA revealed that it is related to tcpA of newly emerged O1 strain and unrelated to tcpA of wild type (classical and El Tor strains). All strains showed variant tcpA and also harbored intact Vibrio Pathogenicity Island (VPI). The expression of all variant alleles was demonstrated by RT-PCR.
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