Journal
CURRENT MEDICINAL CHEMISTRY
Volume 26, Issue 40, Pages 7166-7195Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867325666180904125400
Keywords
Nitrogenated heterocycles; pyridine; pyrimidine; biological activities; synthesis; molecular modeling
Funding
- Italian Ministry of Education, Universities, and Research (MIUR) [20190049]
- University of Catania
- University of Pavia
- University of Messina
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Pyridine and pyrimidine derivatives have received great interest in recent pharmacological research, being effective in the treatment of various malignancies, such as myeloid leukemia, breast cancer and idiopathic pulmonary fibrosis. Most of the FDA approved drugs show a pyridine or pyrimidine core bearing different substituents. The aim of this review is to describe the most recent reports in this field, with reference to the newly discovered pyridine-or pyrimidine-based drugs, to their synthesis and to the evaluation of the most biologically DOI : active derivatives. The corresponding benzo-fused heterocyclic compounds, i.e. quinolines and quinazolines, are also reported.
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