Journal
CURRENT MEDICINAL CHEMISTRY
Volume 19, Issue 32, Pages 5501-5512Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986712803833137
Keywords
Adiponectin; adipoR1; adipoR2; adiponectin signaling
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Adiponectin is an adipose tissue-derived hormone, expressed almost exclusively in adipose tissue, with significant anti-diabetic, anti-atherosclerotic, anti-inflammatory and anti-proliferative properties. The anti-carcinogenic effects of adiponectin result from two main mechanisms: a modulation in the signaling pathways involved in proliferation process and a subtle regulation of the apoptotic response. In this review, we present recent findings on the association of adiponectin with the risk of several malignancies (breast, colorectal, liver and prostate cancers), as well as data on underlying molecular mechanisms by which adiponectin plays a substantial role in cancer pathogenesis.
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