Journal
CURRENT MEDICINAL CHEMISTRY
Volume 19, Issue 28, Pages 4731-4741Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986712803341511
Keywords
Activatable fluorescent probes; cancer imaging; FRET; metal ions; neurodegenerative diseases; optical imaging; photon-induced electron transfer
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Activatable fluorescent probes share the unique feature of being turned on only under specific conditions: they are silent when not interacting with a specific target protein, microenvironment, or reactive species. Several activatable fluorescence probes have demonstrated their potential in cell biology study, disease study and diagnosis, and even in the rapidly expanding field of image-guided surgery. In this review, we will summarize progress in the design of activatable probes and their application in studying cell biology or in optical imaging. Some of the most effective examples of activatable fluorescent probes will be presented and their application will be discussed.
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