Journal
CURRENT MEDICINAL CHEMISTRY
Volume 18, Issue 15, Pages 2234-2239Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986711795656054
Keywords
T regulatory cells; indoleamine 2,3-dioxygenase; dendritic cells
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Indoleamine 2,3-dioxygenase (IDO) is an intracellular heme-containing enzyme that catalyzes the initial rate-limiting step in tryptophan degradation along the kynurenine pathway. Recent works have demonstrated a crucial role for IDO in the induction of immune tolerance during infections, pregnancy, transplantation, autoimmunity, and neoplasias. IDO is widely expressed in human tissues and cell subsets, including dendritic cells, where it modulates their function by increasing tolerogenic capacities. The aim of the present paper is to highlight the most recent data about IDO expression in dendritic cells and its role as a potent inducer of T regulatory cells.
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