Journal
CURRENT MEDICINAL CHEMISTRY
Volume 18, Issue 4, Pages 482-496Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986711794480203
Keywords
Aurora kinase; Aurora B; serine-threonine kinase; mitosis; cytokinesis; cancer; inhibitors
Funding
- Italian Ministry of Education (MIUR)
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
Ask authors/readers for more resources
Aurora B is a serine-threonine kinase belonging to the highly conserved Aurora family of mitotic kinases. Aurora B is a chromosomal passenger protein involved in chromosome segregation, spindle-checkpoint, and cytokinesis. Alteration of each of these steps could induce aneuploidy, one of main features, and driving force of cancer progression. The overexpression of Aurora B has been observed in several tumor types, and has been linked with a poor prognosis of cancer patients. In this review we will focus on the role of Aurora B in cancer development, its role as a prognostic marker, and the clinical outcome of recently developed Aurora(s) inhibitors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available