Journal
CURRENT MEDICINAL CHEMISTRY
Volume 18, Issue 29, Pages 4538-4556Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986711797287584
Keywords
5-Fluorouracil (5-FU); anticancer; thymidylate synthase; antimetabolite; toxicity
Funding
- National Natural Science Foundation (NNSF) of China [30901839]
- Intramural Research Foundation of Xi'an Jiaotong University [xjj2009073]
- Fundamental Research Funds for the Central Universities
Ask authors/readers for more resources
5-Fluorouracil (5-FU) is one of the most potent antimetabolites which have been widely used in the treatment of advanced solid tumors. As an anticancer agent, because of its low efficacy and high toxicity, numerous modifications of 5-FU structure have been performed. A great number of novel 5-FU derivatives have been developed with highly efficient and much less toxic. In this paper, the recent development of novel 5-FU derivatives as potent antitumor agents is reviewed and discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available