Journal
CURRENT MEDICINAL CHEMISTRY
Volume 18, Issue 35, Pages 5333-5354Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986711798194324
Keywords
Calcineurin; cyclophilin; FK506-binding protein; immunophilin; immunosuppression; PPIase domain
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The immunophilins are proteins which are capable of influencing the immune response in combination with an immunosuppressive drug. Their natural function, however, is mainly the cis/trans isomerization of peptidyl-prolyl bonds in other proteins. This review lists all immunophilin structure coordinates currently available in the RCSB protein data bank and highlights the key active-site factors that define their catalytic and immunological action. In addition, an overview of biologically-relevant functions is provided for various immunophilin members.
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