Journal
CURRENT MEDICINAL CHEMISTRY
Volume 17, Issue 2, Pages 173-189Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986710790112648
Keywords
DNA specific recognition; small molecules; interaction
Funding
- NSFC (National Science Fund of China [90813031, 20672084, 20621502, 30973605]
- National Key Foundation for Infectious Diseases [2008ZX10003 -005]
- State Key Laboratory of Bio-Organic & Natural Products Chemistry
- Shanghai Institute of Organic Chemistry
- Chinese Academy of Sciences Shanghai [200032]
- State Key Laboratory of Natural and Biomimetic Drugs
- Peking University
- NSFC [20802055]
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DNA exhibits many attractive features in the development of drug design and disease treatment, and there are some successful events for drugs targeting to DNA in clinic use. Nowadays, the specific recognition of DNA by small molecules is the crucial factor of the sustainable development of DNA-target drugs, for the serious side-effects of existing drugs. In this review, we discussed the current efforts of DNA-drug specific interaction that concerned with various DNA recognition models, such as abasic, mismatch or bulge site recognition, specific sequence recognition, and secondary structure recognition. Some compounds are found to show remarkable potential to be ideal drug.
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