Journal
CURRENT MEDICINAL CHEMISTRY
Volume 16, Issue 28, Pages 3716-3739Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986709789104984
Keywords
Antiviral; influenza; inhibitors; drug design; target
Funding
- National Nature Science Foundation of China [36072541]
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Influenza is a disease for deeply affecting millions of people every year. Recently, there has been considerable concern regarding the highly pathogenic H5N1 avian influenza virus, and its human pandemic potential. With developments in viral biology, there are more novel antiviral strategies targeting these viruses. In this review, we will discuss several proven and potential anti-influenza targets, including viral factors (such as hemagglutinin (HA), M2 ion channel protein, RNA-dependent RNA polymerase (RdRp), nucleoprotein (NP), non-structural protein (NS) and neuraminidase (NA)) and host factors (such as v-ATPase, protease, inosine monophosphate dehydrogenase (IMPDH) and intracellular signalling cascades), and their relevant inhibitors.
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