Journal
CURRENT MEDICINAL CHEMISTRY
Volume 16, Issue 7, Pages 854-866Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986709787549253
Keywords
Stem cells; differentiation; DNA repair; CD133; cancer
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Stem cells build and maintain organisms. Accordingly, they are particularly well-protected from damage to DNA and other cellular components. This feature becomes a serious drawback when stem cells transform and develop cancer, because they resist to radiation and chemotherapy. Various mechanisms ensure protection of stem cells. In normal stem cells enhanced DNA repair is often one of them. Whether the same holds for cancer stem cells still is an open question.
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