Journal
CURRENT MEDICINAL CHEMISTRY
Volume 16, Issue 10, Pages 1266-1277Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986709787846578
Keywords
Mitochondria; complex I; oxidative stress; reactive oxygen species; apoptosis; complex I functions
Funding
- National Institute on Aging of the National Institutes of Health [1R01AG025223-01]
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Mitochondria are ubiquitous organelles in eukaryotic cells whose primary function is to generate energy supplies in the form of ATP through oxidative phosphorylation. As the entry point for most electrons into the respiratory chain, NADH: ubiquinone oxidoreductase, or complex I, is the largest and least understood component of the mitochondrial oxidative phosphorylation system. Substantial progress has been made in recent years in understanding its subunit composition, its assembly, the interaction among complex I and other respiratory components, and its role in oxidative stress and apoptosis. This review provides an updated overview of the structure of complex I, as well as its cellular functions, and discusses the implication of complex I dysfunction in various human diseases.
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