Journal
CURRENT MEDICINAL CHEMISTRY
Volume 16, Issue 25, Pages 3215-3242Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986709788803295
Keywords
Thebaine; morphinandiene; opioid activity; dopamine activity; orvinols
Funding
- National Science Foundation [NI61336, F061607]
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The most practical synthetic routes to the preparation of as important pharmaceuticals as oxycodone, naloxone, naltrexone, nalbuphine and buprenorphine have utilized the alkaloid, thebaine, as a starting material. This review intends to focus on chemical transformations of morphinans which resulted in morphinandiene derivatives with well-established and novel pharmacological potencies. These chemical transformations were mainly associated with the formation and substitution of the unique diene structure of the ring C of the morphinan backbone.
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