Journal
CURRENT HYPERTENSION REPORTS
Volume 16, Issue 5, Pages -Publisher
SPRINGER
DOI: 10.1007/s11906-014-0430-3
Keywords
Hypertension; Resistant hypertension; Renal sympathetic denervation; Baroreceptor stimulation; Heart failure; Left ventricular hypertrophy; Cardiac arrhythmias; Vascular remodeling
Categories
Funding
- Medtronic/Ardian
- St. Jude
- Boston Scientific
- Cordis
- Deutsche Forschungsgemeinschaft [KFO 196]
- Deutsche Hochdruckliga
- Deutsche Gesellschaft fur Kardiologie
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Hypertension has wide (30-45 %) prevalence in the general population and is related to important increases in overall cardiovascular morbidity and mortality. Despite lifestyle modifications and optimal medical therapy (three drugs, one being diuretic), about 5-20 % of hypertensives are affected by resistant hypertension. Chronic high blood pressure has adverse effects on the heart and other organs such as the kidneys and vasculature. Renal sympathetic denervation and baroreceptor stimulation are invasive approaches initially investigated to treat resistant hypertension. Their pleiotropic effects appear promising in cardiovascular remodeling, heart failure and arrhythmias and could potentially affect cardiovascular morbidity and mortality.
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