Journal
CURRENT HYPERTENSION REPORTS
Volume 14, Issue 3, Pages 261-269Publisher
SPRINGER
DOI: 10.1007/s11906-012-0267-6
Keywords
Hypertension; Secondary hypertension; Neurogenic; Essential; Vertebral; Basilar; Vertebrobasilar; Elevated; Brainstem; Resistance; Arterial; Sympathetic; SNA; Cushing's
Categories
Funding
- British Heart Foundation
- National Institutes of Health [HL033610]
- Royal Society
- Physiological Society
- British Heart Foundation [FS/11/1/28400, RG/07/006/23634] Funding Source: researchfish
- Medical Research Council [MC_G0900868] Funding Source: researchfish
- MRC [MC_G0900868] Funding Source: UKRI
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There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and hypertensive humans. In this review, we discuss the possible role of brainstem hypoperfusion in driving increased sympathetic activity and hypertension.
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