Journal
CURRENT HYPERTENSION REPORTS
Volume 13, Issue 1, Pages 46-54Publisher
SPRINGER
DOI: 10.1007/s11906-010-0174-7
Keywords
Hypertension; Blood pressure; Cardiovascular disease; Single nucleotide polymorphisms; SNPs; Pathways; GWAS; Genome-wide association studies
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Funding
- National Institutes of Health (NIH) [U01 HL54471, RO1 HL07178205A]
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Blood pressure (BP), hypertension (HT) and cardiovascular disease (CVD) are common complex phenotypes, which are affected by multiple genetic and environmental factors. This article describes recent genome-wide association studies (GWAS) that have reported causative variants for BP/HT and CVD/heart traits and analyzes the overlapping associated gene polymorphisms. It also examines potential replication of findings from the HyperGEN data on African Americans and whites. Several genes involved in BP/HT regulation also appear to be involved in CVD. A better picture is emerging, with overlapping hot-spot regions and with interconnected pathways between BP/HT and CVD. A systemic approach to full understanding of BP/HT and CVD development and their progression to disease may lead to the identification of gene targets and pathways for the development of novel therapeutic interventions.
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