Journal
CURRENT HIV RESEARCH
Volume 8, Issue 1, Pages 73-80Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157016210790416389
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Funding
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01AI025825, R01AI040882]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI025825, R01AI040882] Funding Source: NIH RePORTER
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FIV is a significant pathogen in the cat and is, in addition, the smallest available natural model for the study of lentivirus infections. Although divergent at the amino acid level, the cat lentivirus has an abundance of structural and pathophysiological commonalities with HIV and thus serves well as a model for development of intervention strategies relevant to infection in both cats and man. The following review highlights both the strengths and shortcomings of the FIV/cat model, particular as regards development of antiviral drugs.
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