Journal
CURRENT HIV RESEARCH
Volume 7, Issue 1, Pages 101-108Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157016209787048564
Keywords
AIDS; HIV-1; transcription; inhibitors; Rev; RRE; antiviral
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Funding
- National Natural Science Foundation of China [30772629, 30371686]
- International Cooperation
- Ministry of Science and Technology of China [2003DF000033]
- Research Fund for the Doctoral Program of Higher Education of China [070422083]
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The HIV-1 Rev protein, which traffics through nucleolus and shuttles between nucleus and cytoplasm, facilitates export of unspliced and singly spliced viral transcripts containing RRE RNA by the CRM1 export pathway. Inhibitions of the various stages of Rev-mediated RNA transport can arrest HIV-1 transcriptional process. The current understanding to the mechanism of Rev function, Rev-RRE interaction, as well as inhibitors hereof is reviewed.
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