Journal
CURRENT GENOMICS
Volume 15, Issue 2, Pages 122-129Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389202915666140221005023
Keywords
Aging; Autophagy; Caenorhabditis elegans; Chaperones; Folding; Germline stem cells; Misfolding; Ubiquitin proteasome system
Funding
- Fay and Bert Harbour award
- Israeli Council for Higher Education Alon Fellowship
- Marie Curie International Reintegration grant
- Binational Science Foundation
- Israel Science Foundation
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Protein folding and clearance networks sense and respond to misfolded and aggregation-prone proteins by activating cytoprotective cell stress responses that safeguard the proteome against damage, maintain the health of the cell, and enhance lifespan. Surprisingly, cellular proteostasis undergoes a sudden and widespread failure early in Caenorhabditis elegans adulthood, with marked consequences on proteostasis functions later in life. These changes in the regulation of quality control systems, such as chaperones, the ubiquitin proteasome system and cellular stress responses, are controlled cell-nonautonomously by the proliferation of germline stem cells. Here, we review recent studies examining changes in proteostasis upon transition to adulthood and how proteostasis is modulated by reproduction onset, focusing on C. elegans. Based on these and our own findings, we propose that the regulation of quality control systems is actively remodeled at the point of transition between development and adulthood to influence the subsequent course of aging.
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