Journal
CURRENT GENOMICS
Volume 12, Issue 2, Pages 123-129Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920211795564340
Keywords
Biocatalysts; fungal laccases; heterologous expression; mutagenesis; multicopper enzyme
Funding
- European Union [NMP2-CT2004-505899]
- Agence Nationale de la Recherche [ANR-08-JCJC-0107-01, ANR-09-BLANC-0176]
- Region PACA [DEB10-924 2010-12144]
- Agence Nationale de la Recherche (ANR) [ANR-08-JCJC-0107] Funding Source: Agence Nationale de la Recherche (ANR)
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Laccases (p-diphenol oxidase, EC 1.10.3.2) are blue multicopper oxidases that catalyze the reduction of dioxygen to water, with a concomitant oxidation of small organic substrates. Since the description at the end of the nineteenth century of a factor catalyzing the rapid hardening of the latex of the Japanese lacquer trees (Rhus sp.) exposed to air laccases from different origins (plants, fungi bacteria) have been continuously discovered and extensively studied. Nowadays, molecular evolution and other powerful protein modification techniques offer possibilities to develop tailored laccases for a wide array of applications including drug synthesis, biosensors or biofuel cells. Here, we give an overview on strategies and results of our laboratory in the design of new biocatalysts based on laccases.
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