Journal
CURRENT GENOMICS
Volume 11, Issue 6, Pages 397-401Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920210793175967
Keywords
Aneuploidy; chromosome aberrations; embryonic and fetal development; somatic genomic variations
Funding
- IWT [SBO-60848]
- FWO [G.0320.07]
Ask authors/readers for more resources
Only 25 to 30% of conceptions result in a live birth. There is mounting evidence that the cause for this low fecundity is an extremely high incidence of chromosomal rearrangements occurring in the cleavage stage embryo. In this review, we gather all recent evidence for an extraordinary degree of mosaicisms in early embryogenesis. The presence of the rearrangements seen in the cleavage stage embryos can explain the origins of the placental mosaicisms seen during chorion villi sampling as well as the chromosomal anomalies seen in early miscarriages. Whereas these rearrangements often lead to implantation failure and early miscarriages, natural selection of the fittest cells in the embryo is the likely mechanism leading to healthy fetuses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available