Journal
CURRENT GENETICS
Volume 61, Issue 3, Pages 289-297Publisher
SPRINGER
DOI: 10.1007/s00294-014-0452-z
Keywords
Beauveria bassiana; Alkane degradation; Reactive oxygen species; Antioxidant enzymes
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Funding
- Sao Paulo Research Foundation (FAPESP) of Brazil [2014/01229-4]
- National Council of Scientific and Technical Research (CONICET) of Argentina [PIP0237]
- National Agency for Science and Technology Promotion of Argentina [PICT2012-1964]
- CONICET
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Entomopathogenic fungi mostly attack their insect hosts by penetration through the cuticle. The outermost insect surface is covered by a lipid-rich layer, usually composed of very long chain hydrocarbons. These fungi are apt to grow on straight chain hydrocarbons (alkanes) as the sole carbon source. Insect-like hydrocarbons are first hydroxylated by a microsomal P450 monooxygenase system, and then fully catabolized by peroxisomal beta-oxidation reactions in Beauveria bassiana. In this review, we will discuss lipid metabolism adaptations in alkane-grown fungi, and how an oxidative stress scenario is established under these conditions. Fungi have to pay a high cost for hydrocarbon utilization; high levels of reactive oxygen species are produced and a concomitant antioxidant response is triggered in fungal cells to cope with this drawback.
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