Journal
CURRENT GENETICS
Volume 55, Issue 4, Pages 357-363Publisher
SPRINGER
DOI: 10.1007/s00294-009-0265-7
Keywords
ARS; DNA replication; Gene silencing; ORC
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Funding
- NSERC, Canada
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Autonomously replicating sequences (ARSs) in Saccharomyces cerevisiae have been extensively characterized as both origins of DNA replication and as chromatin repressors/silencers. It has been conclusively shown that the origin and the silencer activities of ARS are substantially, but not entirely interchangeable and that they are modulated by position effects and chromatin environment. It remains unclear how these two quite divergent functions of ARS co-exist. This perspective focuses on recent advances, which have shown that slight differences in ARSs can modulate their affinity for origin recognition complex and their activity as silencers or origins.
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