Journal
CURRENT GENE THERAPY
Volume 9, Issue 5, Pages 341-355Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156652309789753329
Keywords
Oncolytic viruses; tumor microenvironment; angiogenesis; extracellular matrix; cytokines
Categories
Funding
- NINDS/NIH [1R01NS064607, 1K01NS059575, 1R21NS066299]
- NCI/NIH [R21CA133663, R01CA 114004]
- NIH/NCI [P01CA089248]
- NIH/NIMH [R21MH082421]
- NIH/NINDS [R21NS063290, U01NS061811]
- Alliance for Cancer Gene Therapy
- NATIONAL CANCER INSTITUTE [R01CA114004, R01CA150153, R21CA133663, P01CA069246] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R21MH082421] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K01NS059575, R21NS063290, R21NS056203, R01NS064607, R21NS066299, U01NS061811] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Oncolytic viral therapy is a promising biological therapy for the treatment of cancer. Recent advances in genetic engineering have facilitated the construction of custom-built oncolytic viruses that can be exquisitely targeted to tumors by exploiting each cancer's unique biology and their efficacy can be further enhanced by arming them with additional therapeutic genes. Such an approach allows the virus to unload its therapeutic cargo at the tumor site, thereby enhancing its anti-neoplastic properties. While several clever strategies have been recently described using genes that can induce cellular apoptosis/suicide and/or facilitate tumor/virus imaging, viruses armed with genes that also affect the tumor microenvironment present an exciting and promising approach to therapy. In this review we discuss recently developed oncolytic viruses armed with genes encoding for angiostatic factors, inflammatory cytokines, or proteases that modulate the extracellular matrix to regulate tumor vascularization, anti-tumor immune responses and viral spread throughout the solid tumor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available