Journal
CURRENT EYE RESEARCH
Volume 38, Issue 10, Pages 995-1005Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/02713683.2013.827211
Keywords
Cornea; docosahexaenoic acid; docosanoids; lipid mediators; neuroprotectin D1
Categories
Funding
- National Institutes of Health [P30 GM103340, EY005121, NS046741]
- Research to Prevent Blindness
- American Health Assistance Foundation [M2010091]
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Studies in the central nervous system (CNS) and retina have revealed the significance of docosahexaenoic acid (DHA), an essential omega-3, 22 carbon 6 double bond (22:6), fatty acid. DHA is necessary for various functions in the CNS, including neuronal membrane bio- and synaptogenesis in memory and vision, and it is the precursor for docosanoids and neuroprotectin D1 (NPD1; 10R, 17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z hexaenoic acid), a DHA bio-derivative with neuroprotective properties. This review covers three targets in ophthalmology for mediator lipidomics, a subgroup within the field of metabolomics: inflammation, neuroprotection and nerve regeneration. It also discusses the role DHA, NPD1 and other lipid mediators play in these three areas.
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