Journal
CURRENT EYE RESEARCH
Volume 36, Issue 8, Pages 768-773Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/02713683.2011.585734
Keywords
Diabetic macular edema; Diabetic retinopathy; Intravitreal injection; Anti-inflammatory drugs; Ketorolac tromethamine
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Funding
- Fundacao Carlos Chagas Filho de Auxilio a Pesquisa no Estado do Rio de Janeiro- FAPERJ
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Purpose: To evaluate the short-term effect of a single intravitreal injection of commercially available ketorolac tromethamine (KT) in eyes with diabetic macular edema refractory to laser photocoagulation. Methods: Prospective interventional case series. Twenty five patients with diabetic macular edema refractory to laser photocoagulation received a single intravitreal injection of commercially available KT (Toradol (R)), in a dose of 3000 mu g. Examination included assessment of ETDRS-best corrected visual acuity (BCVA), measurement of intraocular pressure and high resolution imaging by optical coherence tomography, preoperatively and 7, 15, and 30 days postoperatively. Results: In the follow up visits at 7, 15 and 30 days, BCVA had improved five or more letters in 20% (95% confidence interval, 7.7-38.9%), 16% (95% confidence interval, 5.3-34.2%) and 28% (95% confidence interval, 13.2-47.7%) respectively. An improvement in macular thickness was also observed, although it has not been statistically significant. Conclusion: This pilot study showed that a single intravitreal injection of 3000 mu g of commercial KT led to a short-term improvement of visual acuity in approximately 30% of eyes with diabetic macular edema refractory to laser photocoagulation.
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