Journal
CURRENT EYE RESEARCH
Volume 34, Issue 2, Pages 99-102Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/02713680802647662
Keywords
apolipoprotein E; apolipoprotein E dimer peptide; epithelial keratitis; foscarnet; herpes simplex virus; trifluorothymidine
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Funding
- National Eye Institute [NEI R01 EY06311, F32EY016316, NIH NEI P30 EY002377]
- Research to Prevent Blindness (RPB) Senior Scientific Award
- LSUHSC Translational Research Initiative Grant
- Research to Prevent Blindness, New York, NY
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Purpose: To compare the antiviral effect of a peptide derived from human apolipoprotein E (1% apoEdp) with 1% trifluorothymidine against HSV-1 thymidine kinase (TK)-positive (HSV-1 McKrae) and with 3% foscarnet against HSV-1 TK-negative (KOS background) in the rabbit eye model of acute HSV-1 epithelial keratitis. Materials and Methods: Topical treatment began three days post-infection and continued for five days. Rabbits were treated 5 times per day with 1% apoEdp, 1% trifluorothymidine, 3% foscarnet, or PBS. Slit lamp examination was performed on a masked basis from post-infection days 3-10 to determine the severity of epithelial keratitis. Results: Topical treatment with 1% apoEdp was as effective as 1% trifluorothymidine against TK-positive and 3% foscarnet against TK-negative HSV-1 epithelial keratitis. Conclusions: ApoEdp 1% has efficacy for the topical treatment of TK-positive and TK-negative ocular herpes in the rabbit eye model. Thus, apoEdp has the potential to be used for treatment of keratitis caused by TK mutants.
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