Journal
CURRENT DRUG TARGETS
Volume 13, Issue 2, Pages 272-284Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945012799201649
Keywords
Nitrosative stress; endothelium; blood-brain barrier; peroxynitrite; cerebral ischemia; vasoprotection
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Funding
- National Natural Science Foundations of China [30973521]
- Science Research Foundation of Chinese Ministry of Health [WKJ2009-2-029]
- Zhejiang Provincial Natural Science Foundation of China [R2100281]
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Nitric oxide/peroxynitrite signaling is associated with manifold neurovascular pathogenic cascades that lead to neurodegenerative diseases, including ischemic stroke, Alzheimer's disease, and vascular dementia. Considerable evidence suggests that reactive nitrogen species as mediators of nitrosative stress could damage biomolecules and subsequently facilitate the breakdown of the highly-structured cellular machinery. Herein, we focus on nitrosative stress signaling, which is intimately associated with endothelial cell injury and blood-brain barrier damage in stroke and neurodegenerative diseases. Unraveling the detrimental role of nitrosative stress signaling in initiating and driving neurovascular pathogenesis may lead to the development of novel vasoprotective strategies via restorative therapies for brain diseases.
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