Journal
CURRENT DRUG TARGETS
Volume 13, Issue 14, Pages 1772-1776Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945012804545470
Keywords
Apoptosis; baicalein; bioavailability; pancreatic cancer; phytochemical; prevention; treatment
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Funding
- NIH [T32 07180-37, P01 AT003960, P01 CA163200]
- Hirshberg Foundation for Pancreatic Cancer Research
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Despite advances in therapy for many of the most common cancers, advances which have led to corresponding improvements in survival rates, progress on the pancreatic cancer front have been slow and mortality rates remain startlingly high. New therapeutic strategies are needed. Phytochemicals are naturally occurring, plant-based substances that have garnered much interest in the research world for their anti-cancer properties, both as therapeutics and as components of the diet for chemoprevention. One particularly ubiquitous group of phytochemicals is the polyphenolic flavonoids. Baicalein, one such flavonoid, which has been widely studied in several malignancies, shows potent activity against pancreatic adenocarcinoma in both in vitro and in vivo studies. The mechanisms by which baicalein accomplishes this have recently been elucidated, and is through an induction of apoptosis in pancreatic cancer cells that are fiercely resistant to cell death. Compounds such as baicalein, offer promise in dietary chemoprevention, as chemotherapeutic adjuvants, or as targeted therapy.
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