Journal
CURRENT DRUG TARGETS
Volume 12, Issue 8, Pages 1188-1193Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945011795906561
Keywords
Rab; GTPase; GTP-binding protein; cancer; genetic disorder
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Funding
- NIH [RO1 GM074692]
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The Rab family of GTPases contains over 60 genes in the human genome and contributes to regulation of intracellular membrane trafficking along endocytic and exocytic pathways as well as specialized pathways in specific cell types. It has become increasingly clear that disruption of the intracellular membrane trafficking system at different stages can cause various diseases. In the past decade, altered expression levels and mutations of Rab GTPases have been associated with diseases such as cancer, Alzheimer's disease, and various genetic disorders. This review discusses the specific Rab GTPases and their involvement in the diseases.
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