Journal
CURRENT DRUG TARGETS
Volume 12, Issue 8, Pages 1194-1201Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945011795906534
Keywords
Rho GTPase; ROCK; PAK; IQGAP; oncogenesis
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Funding
- Susan G. Komen [BCTR0600278]
- Louisiana Board of Regents [LEQSF-RD-A-14]
- National institute of Health [CA115706]
- Louisiana Cancer Research Consortium
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Rho GTPases (Ras homologous family) comprise the largest subfamily cluster of the Ras-homology superfamily. Rho GTPases exist in inactive GDP and active GTP forms. The active forms of the Rho family members bind with numerous effector proteins that are crucial for various biological processes. Accumulating evidence exemplifies the importance of Rho effector proteins in various steps of cancer progression. Here, we highlight the actions of various effectors of Rho members in cancer invasion and metastasis.
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