Journal
CURRENT DRUG TARGETS
Volume 10, Issue 1, Pages 38-41Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945009787122914
Keywords
PDGF-D; cancer; EMT; signaling; therapy; invasion; stem cells; nutrition
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Funding
- National Cancer Institute, NIH [5R01CA-101870-05]
- University of Texas MD Anderson Cancer Center [1P20-CA010193-01]
- NATIONAL CANCER INSTITUTE [R01CA101870] Funding Source: NIH RePORTER
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Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation, transformation, invasion, and angiogenesis by specifically binding to and activating its cognate receptor PDGFR-beta. The functions of PDGF-D in human cancer progression are largely unknown. We discuss here the role of PDGF-D signaling pathway in cancer and how its deregulation is involved in tumor development and progression to metastatic disease.
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