Journal
JOURNAL OF NEUROLOGY
Volume 263, Issue 3, Pages 428-440Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-015-7919-9
Keywords
Glioma; Brain metastases; Nanoparticles; Polymer-based nanocarriers; siRNA; Antibodies
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The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood-brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.
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