Journal
CURRENT DRUG METABOLISM
Volume 20, Issue 3, Pages 203-208Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389200219666180821095355
Keywords
Molecular design; peptibody; mimetibody; phage display; biopanning; peptide; peptide-Fc fusion; immunoinformatics
Funding
- National Natural Science Foundation of China [61571095, 31671361]
- Fundamental Research Funds for the Central Universities of China [ZYGX2005Z006, ZYGX2016J186]
- Sichuan Science and Technology Program [2018HH0154]
Ask authors/readers for more resources
Background: Peptide-Fc fusion drugs, also known as peptibodies, are a category of biological therapeutics in which the Fc region of an antibody is genetically fused to a peptide of interest. However, to develop such kind of drugs is laborious and expensive. Rational design is urgently needed. Methods: We summarized the key steps in peptide-Fc fusion technology and stressed the main computational resources, tools, and methods that had been used in the rational design of peptide-Fc fusion drugs. We also raised open questions about the computer-aided molecular design of peptide-Fc. Results: The design of peptibody consists of four steps. First, identify peptide leads from native ligands, biopanning, and computational design or prediction. Second, select the proper Fc region from different classes or subclasses of immunoglobulin. Third, fuse the peptide leads and Fc together properly. At last, evaluate the immunogenicity of the constructs. At each step, there are quite a few useful resources and computational tools. Conclusion: Reviewing the molecular design of peptibody will certainly help make the transition from peptide leads to drugs on the market quicker and cheaper.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available