Journal
CURRENT DRUG METABOLISM
Volume 14, Issue 3, Pages 351-360Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389200211314030010
Keywords
L-(S,R) Noscapine; glutathione S-transferases (GSTs); cytochrome P-450; biliverdin; alanine transaminase (ALT); and bilirubin
Funding
- UGC, New Delhi, India
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This review introduces the Noscapine, which is being used as an antitussive drug for a long time has been recently discovered as a novel tubulin-binding, anti-angiogenic anticancer drug that causes cell cycle arrest and induces apoptosis in cancer cells both in vitro as well as in vivo. Noscapine is a multifunctional molecule i.e. it possesses various functional moieties. We maneuvered various amenable sites and have synthesized analogs, which might prove to be more efficacious and less cytotoxic. Moreover, development of oral controlled release anticancer formulation of noscapine is severely hampered due to short biological half-life (< 2-h), poor absorption, low aqueous solubility, and extensive first pass metabolism, thereby requiring large doses for effective treatment.
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