Journal
CURRENT DRUG METABOLISM
Volume 13, Issue 8, Pages 1097-1109Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920012802850010
Keywords
Dendrimer; anticancer drug delivery; cancer diagnosis
Funding
- Shanghai Pujiang Program [09PJ1400600]
- National Natural Science Foundation of China [20974019]
- National Basic Research Program of China (973 Program) [2007CB936000]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
- Shanghai Natural Science Foundation [10ZR1400800]
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Dendrimers represent a class of monodispersed synthetic macromolecules with a well defined three-dimensional structure of nanometer dimension in which a series of layered branches regularly extend from a central core molecule. Due to their precise nanoscale sizes, well-defined branched structures, and various surface modifications, dendrimers have been extensively investigated in a wide range of applications in the biomedical field, particularly in the therapeutics and diagnosis of cancer. This article gives an overview of the recent advances of dendrimers and dendrimer-based hybrid nanoparticles for cancer therapeutics and diagnosis applications.
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