Journal
CURRENT DRUG METABOLISM
Volume 13, Issue 8, Pages 1123-1129Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920012802850056
Keywords
Endothelial cells; nanoparticles; cardiovascular diseases
Funding
- National Natural Science Foundation of China [31000451, 30970784]
- National Key Basic Research Program of China (MOST 973) [2009CB930200, 2009CB930100]
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Endothelial cells have very important functions, one of which is their contribution to regulating molecule and nutrient exchanges between the blood and peripheral tissues. Dysfunction of endothelial cells plays an essential role in the progression of cardiovascular diseases (CVD) such as atherosclerosis and coronary heart disease. With the recent progress of nanotechnology, increasing numbers of studies have focused on the effects of nanoparticles on CVD. In this article, we review the biological characters of endothelial cells, evaluate the impacts of nanoparticles on the behavior and functions of endothelial cells, analyze advantages and disadvantages of various nanoparticles, and discuss potential applications of nanoparticles to CVD treatment.
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