Journal
CURRENT DRUG METABOLISM
Volume 13, Issue 8, Pages 1046-1056Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920012802850083
Keywords
Carbon dots; fluorescent probe; nanodiamonds; pharmacokinetics; toxicity
Funding
- National Basic Research Program of China (973 Program) [2011CB933402, 2009CB930200]
- Chinese Natural Science Foundation [21071094]
- Key Project of Chinese Ministry of Education [211053]
- Shanghai Municipal Education Committee [11ZZ82]
- Shanghai Leading Academic Disciplines [S30109]
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The rapid advancement of nanotechnology has brought us some new types of fluorescent probes, which are indispensable for bioimaging in life sciences. Because of their innate biocompatibility, good resistance against photobleaching, long fluorescence lifetime and wide fluorescence spectral region, fluorescent carbon quantum dots (C-Dots) and nanosized diamonds (nanodiamonds, NDs) are gradually evolving into promising reagents for bioimaging. In this review, we summarize the recent achievements in fluorescent C-Dots and NDs with emphases on their preparation, properties, imaging application, pharmacokinetics and toxicity. Perspectives on further investigations and opportunities to develop C-Dots and NDs into the safer and more sensitive imaging probes for both living cells and animal models are discussed.
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