Journal
CURRENT DIABETES REPORTS
Volume 12, Issue 5, Pages 612-622Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11892-012-0305-4
Keywords
Mesenchymal stem cells; Islet transplantation; Type 1 diabetes; Immunomodulation; beta cell function; Immunomodulatory and tissue repair properties
Categories
Funding
- Stanford BioX Interdisciplinary Program
- [NIH/NIBIB (R01EB003806)]
Ask authors/readers for more resources
Islet cell transplantation has therapeutic potential to cure type 1 diabetes (T1D), which is characterized by autoimmune-mediated destruction of insulin-producing beta cells. However, current success rates are limited by long-term decline in islet graft function resulting partially from poor revascularization and immune destruction. Mesenchymal stem cells (MSCs) have the potential to enhance islet transplantation and prevent disease progression by a multifaceted approach. MSCs have been shown to be effective at inhibiting inflammatory-mediated immune responses and at promoting tissue regeneration. The immunomodulatory and tissue repairing properties of MSCs may benefit beta cell regeneration in the context of T1D. This review will elucidate how MSCs can minimize beta cell damage by providing survival signals and simultaneously modulate the immune response by inhibiting activation, and proliferation of several immune cell types. In addition, MSCs can enhance islet graft revascularization, maintaining long-term beta cell viability and function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available