Journal
CURRENT DIABETES REPORTS
Volume 10, Issue 1, Pages 55-60Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11892-009-0090-x
Keywords
Islet; Beta cell; Cholesterol; HDL
Categories
Funding
- Canadian Institutes of Health Research
- Michael Smith Foundation for Health Research Senior Scholar
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beta-cell dysfunction is a critical step in the pathogenesis of type 2 diabetes. The mechanisms responsible for beta-cell death and dysfunction remain incompletely understood, but include glucolipotoxicity, the deleterious metabolic milieu created by high plasma concentrations of glucose and lipid species. Recently, an important role has emerged for cholesterol in this process. In this article, we review recent advances in our understanding of the role of ABCA1 and cholesterol metabolism in beta-cell function, with particular attention to insights gained from human studies.
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